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The Talent Capitalist's avatar

Hard not to see the Regulator being held captive to the same type of special interests that blight all industry such as Sugar, Banking, Pharma.........

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Abhishek Anand's avatar

if you use FDA as a positive example, you are in a fool's paradise. Maybe you should use FAA.

FDA completely failed to ensure that the mrna vaccine companies do proper trials to analyze safety or even effectiveness. The mrna randomized controlled trials (the only reliable method of assessing causality) only showed the reduction in symptomatic PCR-positivity, not in more meaningful outcomes like actually reducing hospitalizations, overall deaths, or transmission: the claims FDA itself promoted without good evidence https://www.bmj.com/content/371/bmj.m4037 . Even after data showing that young men are more at risk after hospitalization after the mrna covid vaccine than covid itself, the FDA continued to promote those vaccines and their mandates.

FDA routinely approves expensive drugs based on surrogate endpoints, not showing effectiveness in reducing actually meaningful outcomes: e.g. https://www.science.org/content/blog-post/aducanumab-approval

As another example, they approved Nexetol just based on LDL lowering, not based on actual reduction in cardivascular deaths or heart attacks (https://www.acc.org/latest-in-cardiology/articles/2020/02/24/10/09/fda-approves-bempedoic-acid-for-treatment-of-adults-with-hefh-or-established-ascvd read the last sentence), even though it is well known that many drugs that lower LDL actually increase cardiovascular deaths, e.g. Clofibrate https://www.nejm.org/doi/full/10.1056/NEJMoa0706628

FDA routinely hinders cheap but effective agents like NMN (https://twitter.com/davidasinclair/status/1603513997768138756)

and NAC, which is effective in many ways and has decades of proven safety trackrecord.

In summary, the FDA is more about protecting the financial interests of the pharma companies they have CoI with, much less about protecting consumers.

I do see a need for an agency that ensures that supplements/medicines have no contamination and have exactly what is stated in the label. But that could be done by market forces, such as "Amazon/ConsumerReports Certified Integrity" label

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