Drug companies race to fix muscle mass loss caused by Ozempic, doctors discover a new cause for women's autoimmune conditions, and Adam Neumann tries to buy back WeWork
I'm not sure drugs will fix this. I only studied this briefly while at Noom, but the hypotheses I heard from the scientific community were that the muscle loss is not from the drug itself, but just from the nutritional profile of eating habits caused by appetite suppression.
No known drug other than an anabolic steroid is going to reduce muscle loss if someone is not lifting weights and eating sufficient high-quality protein.
If you do any calorie restriction, with or without these drugs, and don't eat enough protein or do resistance training, you're going to lose mostly muscle mass.
This is why someone experiencing disordered eating such as bulimia or anorexia does not have the same body composition at low weights as someone who works out and eats protein-rich diets.
Protein-rich foods like meat or beans, and even some fatty foods can feel unappetizing or too filling when you feel full. On the other hand, because of the changes to the digestive tract, protein-rich palatable foods such as dairy or protein shakes can cause discomfort and are not tolerated well by many people using these drugs.
So, like most people, you don't exercise with resistance training regularly, you no longer have an appetite for anything other than highly palatable and usually "light" or "liquid" foods, and are losing weight at a pace faster than most bodies should for maximum muscle conservation.
Friedberg shared that point on the pod a couple weeks ago, that a lot of the weight you lose on Ozempic/ wegovy is from your lean muscle mass.
Personally think the who point of getting on any GLP1 should be for obese people to help develop healthy eating patterns and habits before weaning off of it. Otherwise you’re just opening the door for muscle related frailty and fall risks in later life. This shouldn’t be a drug for “healthy people” to lose weight. Nothing is a panacea
I'm not sure drugs will fix this. I only studied this briefly while at Noom, but the hypotheses I heard from the scientific community were that the muscle loss is not from the drug itself, but just from the nutritional profile of eating habits caused by appetite suppression.
No known drug other than an anabolic steroid is going to reduce muscle loss if someone is not lifting weights and eating sufficient high-quality protein.
If you do any calorie restriction, with or without these drugs, and don't eat enough protein or do resistance training, you're going to lose mostly muscle mass.
This is why someone experiencing disordered eating such as bulimia or anorexia does not have the same body composition at low weights as someone who works out and eats protein-rich diets.
Protein-rich foods like meat or beans, and even some fatty foods can feel unappetizing or too filling when you feel full. On the other hand, because of the changes to the digestive tract, protein-rich palatable foods such as dairy or protein shakes can cause discomfort and are not tolerated well by many people using these drugs.
So, like most people, you don't exercise with resistance training regularly, you no longer have an appetite for anything other than highly palatable and usually "light" or "liquid" foods, and are losing weight at a pace faster than most bodies should for maximum muscle conservation.
Friedberg shared that point on the pod a couple weeks ago, that a lot of the weight you lose on Ozempic/ wegovy is from your lean muscle mass.
Personally think the who point of getting on any GLP1 should be for obese people to help develop healthy eating patterns and habits before weaning off of it. Otherwise you’re just opening the door for muscle related frailty and fall risks in later life. This shouldn’t be a drug for “healthy people” to lose weight. Nothing is a panacea
Thank you for all that you share, very insightful, high-level intellectual content.