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The findings are intriguing! However, I suspect they won’t hold up under broader scrutiny. First, the human samples were taken from individuals who lost weight through bariatric surgery, not through GLP-1 treatments or sustained changes in behavior and diet, which could lead to different epigenetic outcomes. Second, the mouse samples were collected just weeks after a diet change, arguably too early to observe longer-term epigenetic adaptations driven by consistent behavioral shifts. Epigenetic markers are dynamic and likely reflect sustained behavior over time—this study’s design may simply have been insufficient to reveal that.

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